Essentials of Physical Pharmacy
  by C.V.S. Subrahmanyam
 
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   ISBN 978-93-85529-10-8; 2nd Ed. 2017; pp.viii+552

   Delhi price: 330      Outside Delhi price: 350      Overseas price : 990

 About The Book  

Physical pharmacy is concerned with the fundamental physical and chemical properties of matter or substanceand their impact on biological activity. The knowledge on these principles is necessary to the pharmacist primarily engaged in the manufacture of formulations. This content area is known to go by many titles by different universities, namely Physical Chemistry, Physical Pharmacy I combined with pharmaceutical analysis.

   In this edition, every chapter begins with Objectives listed, followed by content and Summary. Every chapter has newer topics included, applications separated and highlighted for better understanding, Question Bank updated to include MCQs. Appendix includes logical reasoning to Comments from each chapter.

   Special emphasis has been maintained on
         1. Applications of principles
         2. Illustrations for concept mapping
         3. Comments to encourage logical reasoning
         4. Question Bank with MCQs to help with competitive examinations
This book will also serve as a ready reference for the industrial pharmacist also.

 Content


Chapter 1. CHEMICAL BONDING
     Valence Bond Theory
     Classification of Chemical Bonds
     Atomic Orbital Theory-Bond Formation
     Molecular Orbital Theory
     Question Bank

Chapter 2. INTERMOLECULAR FORCES
     Factors Influencing Intermolecular Forces
     Question Bank

Chapter 3. GASEOUS STATE
     Ideal Gas Equation
     Real Gases-van der Waals Equation
     Dalton’s Law of Partial Pressures
     Graham’s Law of Diffusion of Gases
     Question Bank

Chapter 4. LIQUID STATE
     Characteristic Properties of Liquids
     Boiling Point
     Internal Pressure
     Liquefaction of Gases
     Aerosols
     Question Bank

Chapter 5. SOLID STATE
     Classification
     Crystals and Crystal Systems
     Laws of Crystallography
     Crystal Habit
     Polymorphism
     Pseudomorphism
     Isomorphism
     Amorphous Solids
     Characterisation of Crystals
     Question Bank

Chapter 6. PHASE RULE AND PARTIALLY MISCIBLE LIQUIDS
     Phase Rule
     Phase Diagram-One Component System, Water
     Phenol-Water System
     Triethylamine-Water System
     Nicotine-Water System
     Influence of Foreign Substances
     Method of Determination
     Question Bank

Chapter 7. THERMODYNAMICS—BASIC CONCEPTS AND FIRST LAW
     General Principles
     First Law of Thermodynamics
     Work of Expansion against a Constant Pressure
     Isothermal Work of Expansion of Gases
     Enthalpy
     Question Bank

Chapter 8. SECOND AND THIRD LAWS OF THERMODYNAMICS
     Spontaneous Process
     Entropy
     Second Law of Thermodynamics
     Heat Engine
     Free Energy
     Third Law of Thermodynamics
     Question Bank

Chapter 9. THERMOCHEMISTRY
     Thermochemical Reactions—Conditions
     Heat Expressions for Chemical Reactions
     Hess Law of Constant Heat Summation
     Question Bank

Chapter 10. PHYSICAL PROPERTIES OF DRUG MOLECULES
     Group Contribution Methods
     Dielectric Constant
     Dipole Moment
     Induced Polarizability—Induced Dipole Moment
     Refractive Index and Molar Refraction
     Optical Rotation
     Viscosity
     Surface Tension
     Question Bank

Chapter 11. SOLUBILITY OF LIQUIDS IN LIQUIDS
     Methods of Expressing Concentration
     Miscible Liquids
     Ideal Solutions
     Nonideal Solutions or Real Solutions
     Fractional Distillation
     Azeotropic Distillation
     Steam Distillation
     Question Bank

 
Chapter 12. DILUTE SOLUTIONS–COLLIGATIVE PROPERTIES
     Lowering of Vapour Pressure
     Osmotic Pressure
     Depression of Freezing Point
     Elevation of Boiling Point
     Question Bank

Chapter 13. SOLUTIONS OF ELECTROLYTES
     Arrhenius Theory of Electrolytic Dissociation
     Van’t Hoff Theory of Solutions
     Modern Theories of Strong Electrolytes
     Conductance of Electrolytes
     Electrolysis
     Faraday’s Laws of Electrolysis
     Question Bank

Chapter 14. THEORIES OF ACIDS AND BASES—IONIC EQUILIBRIA
     Bronsted-Lowry Theory
     Lewis Electronic Theory
     Ionization of Water-Ionic Product
     Dissociation and Dissociation Constant
     Method of Determination of Dissociation Constant
     Ionization of Polyprotic Electrolytes
     Extent of Ionization
     Question Bank

Chapter 15. THE pH AND SORENSEN’S SCALE
     The pH Indicators
     Measurement of pH
     Question Bank

Chapter 16. BUFFER SOLUTIONS
     Buffer Systems-Composition and Examples
     Buffer Action-Mechanisms
     Buffer Equation-Henderson-Hasselbalch Equation
     Buffer Capacity
     Buffers in Biological Systems
     Factors Influencing pH of a Buffer Solution
     Preparation of Buffer Solutions
     Question Bank

Chapter 17. BUFFERED ISOTONIC SOLUTIONS
     Definitions of Solutions Relating to Tonicity
     Methods of Adjusting the Tonicity
     Question Bank

Chapter 18. SALT HYDROLYSIS
     Classification of Salts
     Pharmaceutical Salts
     Salt of a Weak Acid and a Strong Base
     Salt of a Weak Base and a Strong Acid
     Salt of a Weak Acid and a Weak Base
     Salt of a Strong Acid and a Strong Base
     Methods of Analysis
     Question Bank

Chapter 19. SOLUBILITY OF GASES IN LIQUIDS
     Factors Influencing Solubility of Gases in Liquids
     Ostwald’s Solubility Coefficient
     Question Bank

Chapter 20. SOLUBILITY OF SOLIDS IN LIQUIDS
     Determination of Solubility of Solids in Liquids
     Factors Influencing Solubility of Drugs
     Theories of Solutions
     Solubility Parameter
     Question Bank

Chapter 21. DISTRIBUTION LAW
     Nernst Distribution Law
     Measurement of Partition Coefficient
     Influence of Molecular Association on Partition Coefficient
     Influence of Dissociation on Partition Coefficient
     Applications
     Question Bank

Chapter 22. ELECTROMOTIVE FORCE AND OXIDATION-REDUCTION
     Electrochemical Cells
     Single Electrode Potential
     Reversible and Irreverssible Cells
     Measurement of Emf and Electrode Potentials
     Electrochemical Series
     Concentration Cells
     Types of Electrodes
     Oxidation and Reduction
     Question Bank

APPENDIX-I : Units and Constants
APPENDIX-II : Notations/Abbreviations and Inter Conversion of Units
APPENDIX-III : Definitions and Meanings
APPENDIX-IV : All in Twos—Know Them Well
APPENDIX-V : Bibliography
APPENDIX-VI : Answers to Numerical Problems