Laboratory Manual of Pharmaceutical Organic Chemistry-I
  by N.M. Raghavendra & Sayan Dutta Gupta
 
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   ISBN 978-81-85731-81-0; 1st Ed. 2013; pp.viii+112

   Delhi price: 100      Outside Delhi price: 105      Overseas price : 300

 About The Book  

This manual coves the reaction mechanisms with reference to synthesis of medicinal organic compounds, elemental analysis and functional group analysis.
It gives knowledge about organic synthesis and qualitative analysis of organic compounds to graduate and post graduate students.
    Special emphasis is laid on the following:
        1. Mechanism of reaction of organic compounds
        2. Uses of the synthesized compounds
        3. Question bank
        4. Appendices depicting chemical formulas, abbreviations, signs and symbols.

 Content


1. Organic Chemistry Laboratory Techniques
    1.1. General instructions for safe working in the organic chemistry laboratory
    1.2. Hazards in organic chemistry laboratory
    1.3. General laboratory apparatus
    1.4. Special reaction techniques
    1.5. Workup and purification
    1.6. Determination of physical constants
    1.7. Recording of results

2. Preparations
    2.1. Nitration
          2.1.1. Preparation of nitrobenzene
          2.1.2. Preparation of m-dinitrobenzene
          2.1.3. Preparation of p-bromonitrobenzene
          2.1.4. Synthesis of p-nitroaniline
    2.2. Oxidation
          2.2.1. Synthesis of phenylacetic acid from aceto-phenone (Oxidation by Lead tetraacetate)
          2.2.2. Synthesis of benzoic acid (Oxidation by potassium permanganate)
    2.3. Reduction
          2.3.1. Preparation of p-nitrobenzyl alcohol (Reduction with sodium borohydride)
          2.3.2. Preparation of m-nitro aniline from m-dinitrobenzene
          2.3.3. Preparation of benzhydrol from benzophenone
          2.3.4. Preparation of cyclohexa-2,5-diene carboxylic acid
    2.4. Hydrolysis
          2.4.1. Preparation of benzoic acid from benzamide
          2.4.2. Preparation of p-bromoaniline from p-bromoacetanilide
    2.5. Halogenation
          2.5.1. Preparation of p-iodoaniline
          2.5.2. Preparation of p-bromoacetanilide from acetanilide
          2.5.3. Synthesis of 2,4,6-tribromoaniline
          2.5.4. Preparation of Iodoform from acetone
    2.6. Esterification
          2.6.1. Synthesis of n-butyl acetatae
    2.7. Acetylation
          2.7.1. Preparation of acetanilide from aniline
          2.7.2. Synthesis of aspirin from salicylic acid
    2.8. Etherification
          2.8.1. Preparation of Methyl β-napthyl methyl ether (nerolin) from β-napthol

3. Qualitative Analysis
    3.1. Preliminary studies
    3.2. Elemental analysis
    3.3. Solubility studies
    3.4. Functional group identification

APPENDIX-I : Chemical Formulas
APPENDIX-II : Abbreviations
APPENDIX-III : Signs and Symbols