Textbook of Physical Pharmaceutics
  by C.V.S. Subrahmanyam
 
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   ISBN 978-81-85731-98-8; 3rd Ed. 2015; pp. viii+560

   Delhi price: 330      Outside Delhi price: 350      Overseas price : 990

 About The Book  

Physical pharmaceutics is a pharmaceutical material science that is concerned with the physical and chemical principles of materials (drugs and other additives) that go into the formulation of dosage forms. This book consists of 11 Chapters: Chemical Kinetics, Drug Stability, Drug Dissolution, Drug Diffusion, Interfacial Phenomena, Micromeritics, Rheology, Complexation—Protein Binding, Colloidal Dispersions, Suspensions and Emulsions. Essentially, this book concentrates on the two sections, namely Preformulation and Dispersion Dosage Forms.

   In this edition, objectives are included at the beginning of the chapter and summary is appended at the end of the chapter. Each chapter is expanded to include newer topics. A few aspects are: factors influencing the chemical reactions, ICH, WHO guidelines to stability testing, techniques of powder flow evaluation are added in this edition. Efforts were made to include numerical examples.

   Special emphasis was maintained on the lines of expectations.
          1. Application of principles
          2. A number of illustrations on the lines of concept mapping
          3. Comment type questions and answers
          4. Question bank
          5. MCQs and answers

This book will also serve as a ready reference for the industrial pharmacist also.

 Content


   Greek Alphabets

Section One—PREFORMULATION

Chapter 1. CHEMICAL KINETICS
     Molecularity of Reaction
     Order of Reaction
     Determination of Order
     Comparison of Different Orders
     Generalised Rate Expression
     Rate Determining Step
     Question Bank

Chapter 2. DRUG STABILITY
     Physical Degradation of Pharmaceutical Products
     Chemical Decomposition of Drugs—Preventive Measures
     Influence of Light on Drug Decomposition
     Influence of Temperature on Drug Decomposition
     Chemical Stability Testing—Dosage Forms
     Storage
     Question Bank

Chapter 3. DISSOLUTION
     Dissolution - Drug Absorption
     Dissolution - Tablets and Capsules
     Mathematical Treatment - Dissolution
     Factors Influencing Dissolution
     Dissolution Test Apparatus
     Vitro - In Vivo Correlations of Dissolution
     Powder Dissolution - The Hixson-Crowell Cube Root Law
     Question Bank

Chapter 4. DIFFUSION
     Steady State Diffusion
     Methods and Procedures
     Transport of Drugs Across Gastrointestinal Tract
     Diffusion Controlled Release—Higuchi’s Equation
     Question Bank

Chapter 5. INTERFACIAL PHENOMENA
     General Principles
     Determination of Surface and Interfacial Tensions—Methods
     Energetics of Liquid Surfaces
     Spreading Coefficient
     Adsorption at Liquid Interfaces
     Adsorption at Solid Interfaces
     Electrical Properties of Interfaces
     Question Bank

Chapter 6. MICROMERITICS
     Particles—Characteristics
     Powders—Characteristics
     Powders—Particle Size Distribution
     Powders—Distribution Curves—Analysis of Data
     Particle Size Determination—Methods
     Powder Surface Area—Methods
     Derived Properties of Powders
     Question Bank

Chapter 7. RHEOLOGY
     Concept of Viscosity
     Factors Influencing the Viscosity
     Newtonian Flow
     Non-Newtonian Flow
     Thixotropy
     Determination of Flow Properties
     Question Bank

Chapter 8. COMPLEXATION—PROTEIN BINDING
     Metal Complexes
     Organic Molecular Complexes
     Inclusion Complexes
     Methods of Analysis
     Protein Binding
     Question Bank

 
Section Two—DISPERSION DOSAGE FORMS

Chapter 9. COLLOIDS
     Characteristics of Dispersed Phase
     Classification of Colloidal Dispersions
     Purification of Colloidal Dispersions
     Stability of Colloids
     Sensitization and Protective Colloidal Action
     Optical Properties
     Kinetic Properties
     Electrical Properties
     Question Bank

Chapter 10. SUSPENSIONS
     Classification of Suspensions
     Particle-Particle Interaction and Behaviour
     Interfacial Properties of Solids
     Factors Influencing Settling
     Physical Stability
     Formulation of Suspensions
     Rheologic Considerations
     Preparation of Suspensions
     Question Bank

Chapter 11. EMULSIONS
     Classification of Emulsions
     Appearance and Identification
     Causes for Thermodynamic Instability
     Emulsifying Agents
     Emulsifying Agents—Mechanisms of Action
     Physical Instability—Markers
     Factors Which Improve Physical Stability
     Phase Inversion
     Evaluation of Physical Stability of Emulsions
     Preservation of Emulsion
     Rheologic Properties of Emulsion
     Preparation of Emulsions
     Question Bank

APPENDIX-I : Answers to the Comments
APPENDIX-II :Answers to Numerical Problems
APPENDIX-III : Key to the MCQs
APPENDIX-IV : Definitions and Meanings
APPENDIX-V : All In Twos—Know Them Well
APPENDIX-VI : Bibliography
Appendix-VII : Glossary of Symbols
Appendix-VIII : Greek Alphabets and Multiplication of Units
Appendix-IX : Some notations of Units and their Abbreviations in SI units
Appendix-X : Interconversion of Units