Physical Pharmaceutics-II
  by C.V.S. Subrahmanyam
 
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   ISBN 978-93-85529-21-4; 1st Ed. 2019; pp. viii+440

   Delhi price: 300      Outside Delhi price: 315      Overseas price : 900

 About The Book  

Pharmacy Council of India has introduced uniform B.Pharm syllabus throughout the country and the nomenclature Physical Pharmaceutics-II pertains to Semester IV (vide no. 6, 7 and 8 of the Bachelor of Pharmacy course regulations 2014) throughout India. The present title is a continuation of earlier title Textbook of Physical Pharmaceutics.

   The scope of this book is to understand the principles of physical and chemical properties of drugs and excipients that have direct relevance in the formulations of drugs. This book is attempted to develop topics in the direction of utility in the production of pharmaceuticals. This knowledge helps in selecting the right kind of substance for the manufacture of the dosage form.

   Special emphasis is on:
          1. Application of principles
          2. A number of illustrations on the lines of concept mapping
          3. Comment type questions and answers
          4. MCQs and key and question bank


This book will also serve as a ready reference for the industrial pharmacist also.

 Content


1. COLLOIDAL DISPERSIONS
     Characteristics and Properties of Dispersed Phase
     Classification of Colloidal Dispersions
     Purification of Colloidal Dispersions
     Stability of Colloids
     Sensitization and Protective Colloidal Actions
     Optical Properties
     Kinetic Properties
     Electrical Properties
     Question Bank

2. POLYMERS—PHYSICOCHEMICAL PROPERTIES
     Applications of Polymers
     Classification of Polymers
     Characterization of Polymers
     3. RHEOLOGY
     Concepts of Viscosity
     Factors Influencing the Viscosity
     Newtonian Systems
     Non-Newtonian Systems
     Thixotropy—Formulation Development
     Flow of Fluids-Methods of Determination
     Question Bank

4. COMPACTION—DEFORMATION OF SOLIDS
     General Principles
     Applied Force—Deformation of Solids
     Compression—Heckel Equations
     Consolidation
     Decompression
     Compaction at High Load
     Compression Properties
     Question Bank

5. COARSE DISPERSIONS—SUSPENSIONS
     Classification of Suspensions
     Particle—Particle Interaction and Behavior
     Interfacial Properties of Solids
     Factors Influencing Particle Settling
     Crystal Growth and Polymorphism
     Physical Stability
     Formulation of Suspensions
     Rheological Considerations
     Preparation of Suspensions
     Question Bank

6. COARSE DISPERSIONS—EMULSIONS
     Classification of Emulsions
     Appearance and Identification
     Thermodynamic Causes for Instability
     Emulsifying Agents
     Emulsifying Agents-Mechanisms of Action
     Physical Stability-Markers
     Factors Improving Physical Stability
     Phase Inversion
     Evaluation of Physical Stability of Emulsions
     Preservation of Emulsions
     Rheological Properties of Emulsion
     Formulation of Emulsions - HLB Method
     Question Bank

 
7 MICROMERETICS
     Particles—Characteristics
     Powder—Characteristics
     Powders—Particle Size Distribution
     Powders—Distribution Curves-Analysis of Data
     Particle Size Determination-Methods
     Powder Surface Area-Methods
     Derived Properties of Powders
     Question Bank

8 CHEMICAL KINETICS
     Molecularity of Reaction
     Order of Reactions
     Determination of Order
     Comparison of Different Orders
     Chemical Factors Affecting Chemical Degradation
     Physical Factors Affecting Chemical Degradation
     Influence of Temperature on Chemical Degradation
     Temperature—Mechanisms of Chemical Reactions
     Question Bank

9 DRUG STABILITY
     Physical Degradation of Pharmaceutical Products
     Solid State Drug Stability
     Chemical Degradation of Drugs – Preventive Measures
     Chemical Stability Testing—Dosage Forms
     Storage of Pharmaceuticals
     ICH-Stability Guidance—Basic Principles
     WHO-Stability Guidance—Basic Principles
     Question Bank

APPENDIX I : Answers to Comments
APPENDIX II : Answers to Numerical Problems
APPENDIX III : Key to the Multiple Choice Questions
APPENDIX IV : Definitions and Meanings
APPENDIX V : All in Tows — Know them Well
APPENDIX VI : Bibliography
APPENDIX VII : Glossary of Symbols and Abbrevations
APPENDIX VIII : Greek Alphabets and Multiplication of Units
APPENDIX IX : Some Notations of Units and their Abbreviations in SI Units
APPENDIX X : Interconversion of Units