Physical Pharmaceutics-I
  by C.V.S. Subrahmanyam
 
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   ISBN 978-93-85529-20-7; 1st Ed. 2019; pp. viii+552

   Delhi price: 400      Outside Delhi price: 420      Overseas price : 1200

 About The Book  

Pharmacy Council of India has introduced uniform B.Pharm syllabus throughout the country and the nomenclature Physical Pharmaceutics-I pertains to Semester III (vide no. 6, 7 and 8 of the Bachelor of Pharmacy course regulations 2014) throughout India. The present title is a continuation of earlier title Essential of Physical Pharmacy.

   The title ‘Physical Pharmaceutics-I’ is to understand the various physical and physicochemical properties of the substances (drugs and excipients), which allows the pharmacist to select the right kind of substance for the manufacture of the dosage form. These also enable to design the right kind of environment desirable in the production and storage of the medicament. The physical and chemical principles and their impact on biological activity are important. Applications are separated and highlighted.

   Special emphasis is on:
          1. Application of principles
          2. A number of illustrations on the lines of concept mapping
          3. Comment type questions and answers
          4. MCQs and key and question bank


This book will also serve as a ready reference for the industrial pharmacist also.

 Content


Chapter 1. SOLUBILITY PHENOMENON
     Mechanisms of Interactions—Intermolecular Forces
     Factors Influencing the Intermolecular Forces
     Classification of Solvents for the Solubility
     Methods of Expressing Solubility
     Question Bank

Chapter 2. SOLUBILITY OF SOLIDS IN LIQUIDS
     Determination of Solubility of Solids in Liquids
     Factors Influencing Solubility of Drugs
     Theories of Solutions
     Solubility Parameters
     Question Bank

Chapter 3. DRUG DISSOLUTION
     Dissolution-Drug Absorption
     Dissolution-Tablets and Capsules
     Theories of Dissolution
     Mathematical Treatment - Dissolution
     Factors Influencing Dissolution
     Dissolution Test Apparatus
     Vitro-In Vivo Correlations of Dissolution
     Powder Dissolution—The Hixson Crowell Cube Root Law
     Question Bank

Chapter 4. DIFFUSION
     Steady State Diffusion
     Methods and Procedures
     Transport of Drugs Across Gastrointestinal Tract
     Diffusion Controlled Release—Higuchi Equation
     Biopharmaceutics Classification System
     Question Bank

Chapter 5. SOLUBILITY OF GASES IN LIQUIDS
     Factors Influencing Solubility of Gases in Liquids
     Ostwald’s Solubility Coefficient
     Question Bank

Chapter 6. SOLUBILITY OF LIQUIDS IN LIQUIDS
     Miscible Liquids
     Ideal Solutions
     Non-ideal Solutions or Real Solutions
     Question Bank

Chapter 7. PARTIALLY MISCIBLE LIQUIDS
     Phenol—Water System
     Triethylamine—Water System
     Nicotine—Water System
     Influence of Foreign Substances
     Method of Determination
     Question Bank

Chapter 8. DISTRIBUTION LAW
     Measurement of Partition Coefficient
     Influence of Molecular Association on Partition Coefficient
     Influence of Dissociation on Partition Coefficient
     Applications
     Question Bank

Chapter 9. GASEOUS STATE
     Ideal Gas Equation
     Real Gases-van der Waals Equation
     Dalton’s Law of Partial Pressures
     Graham’s Law of Diffusion
     Question Bank

Chapter 10. LIQUID STATE
     Characteristic Properties of Liquids
     Liquefaction of Gases
     Supercritical Fluids
     Liquid Crystals (Meso) Phase
     Liquid Complexes
     Micellar Solubilization
     Aerosols—Inhalers
     Question Bank

 
Chapter 11. SOLID STATE
     Classification
     Crystals and Crystal Systems
     Laws of Crystallography
     Crystal Habit
     Physical States of Drug Solids
     Characterization of Crystals
     Hygroscopicity—Moisture-Humidity
     Question Bank

Chapter 12. PHYSICOCHEMICAL PROPERTIES OF DRUG MOLECULES
     Group Contribution Methods
     Dielectric Constant
     Dipole Moment
     Induced Polarizability—Induced Dipole Moment
     Refractive Index and Molar Refraction
     Optical Rotation
     Dissociation and Dissociation Constant
     Methods of Determining Dissociation of Constant
     Question Bank

Chapter 13. SURFACE AND INTERFACIAL PHENOMENA
     General Principles
     Surface and Interfacial Tensions-Methods
     Energetics of Liquid Surfaces
     Spreading Coefficient
     Adsorption at Liquid Interfaces
     Adsorption at Solid Interfaces
     Electrical Properties of Interfaces
     Question Bank

14. SORENSEN’S PH SCALE
     The pH Indicators
     Measurement of pH
     Question Bank

15. BUFFER SOLUTIONS
     Buffer Systems—Composition and Examples
     Buffer Action—Mechanisms
     Buffer Equation—Henderson-Hasselbalch
     Equation
     Buffer Capacity
     Buffers in Biological Systems
     Factors Influencing pH of a Buffer Solution
     Preparation of Buffer Solutions
     Question Bank

16. BUFFERED ISOTONIC SOLUTIONS
     Definitions of Solutions Relating to Tonicity
     Methods of Adjusting the Tonicity
     Question Bank

17. COMPLEXATION AND PROTEIN BINDING
     Metal Complexes
     Organic Molecular Complexes
     Inclusion Complexes
     Analysis of Complexes—Methods
     Protein Binding
     Question Bank

APPENDIX-I : Answers to the Comments
APPENDIX-II :Answers to Numerical Problems
APPENDIX-III : Key to the MCQs
APPENDIX-IV : Definitions and Meanings
APPENDIX-V : All In Twos—Know Them Well
APPENDIX-VI : Glossary of Symbols
Appendix-VII : Bibliography
Appendix-VIII : Greek Alphabets and Multiplication of Units
Appendix-IX : Some notations of Units and their Abbreviations in SI units
Appendix-X : Interconversion of Units