Textbook of Biopharmaceutics and Pharmacokinetics—Concepts & Applications
  by C.V.S. Subrahmanyam
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   ISBN 978-81-85731-94-0; Second Ed. 2015, Reprint 2018; pp.vii+680;

   Delhi price: 390      Outside Delhi price: 410      Overseas price : 1170

 About The Book  

The book involves the quantification of drug in different processes, such as absorption, distribution, biotransformation and excretion. Several these aspects are important in the clinical situations. This is a basic level book which is normally important for third/final year of B. Pharm. course. These topics are so important that at PG level also these are included. The students of IV year, Bachelor of Pharmacy have been expressing the need for a simple book. This book will help learning calculating the pharmacokinetics parameters.

The book is broadly divided into Biopharmaceutics part and Pharmacokinetics part. Special emphasis is given to include the following:
     1. Conceptualisation of principles.
     2. Applications of principles.
     3. A number of illustrations.
     4. Question bank.


Chapter 1. Introduction to Biopharmaceutics
     Fate of Drug in the Body
     Experimental Studies—Models
     Question Bank

Chapter 2. Drug Level-time Curves and Therapeutic Activity
     Blood Drug Level-Time Analysis
     Blood Drug Level-Time Curves—Routes of Administration
     Blood Drug Level -Time Curves—Therapeutic Activity
     Urinary Drug Level-Time Analysis
     Urinary Drug Level-Time Curves
     Salivary Drug Level-Time Analysis
     Drug Concentration in Feces
     Question Bank

Chapter 3. Drug Dissolution
     Dissolution—Drug Absorption
     Dissolution—Tablets and Capsules
     Mathematical Treatment - Dissolution
     Theories of Dissolution
     Factors Influencing Dissolution
     Dissolution Test Apparatus
     Question Bank

Chapter 4. Drug Absorption—Factors Influencing
     Gastrointestinal Tract—Physiology
     Mechanisms of Drug Absorption in Gastrointestinal Tract
     Biological Factors Influencing Drug Absorption
     Metabolic Factors Influencing Drug Absorption
     Physicochemical Factors Influencing Drug Absorption
     Dietary Components Influencing Drug Absorption
     Drug Absorption—Experimental Models
     Formulation Related Factors Affecting Drug Absorption
     Role of Dosage Forms on Drug Absorption
     Role of Manufacturing/Processing Variables on Drug Absorption
     Absorption of Drugs from Non-oral Extravascular Routes
     Question Bank

Chapter 5. Dosage Form Evaluation—Bioavailability
     General Principles
     Extent of Bioavailability
     Rate of Bioavailability
     Assessing Bioavailability—Methods
     Multiple Dosing—Bioavailability
     In Vitro Bioavailability Studies (Dissolution)
     In Vitro—In Vivo Correlations (IVIVC)
     Biopharmaceutical Classification System
     Question Bank

Chapter 6. Dosage Form Evaluation—Bioequivalence
     General Principles
     Bioequivalence Requirement—Criteria
     Bioequivalence Requirement—Criteria for Waiver
     Pharmacokinetic Parameters—Logarithmic Transformations
     Bioequivalence Studies—Methodology
     Statistical Analysis
     Question Bank

Chapter 7. Drug-Drug Interactions
     Multi-drug Therapy—Importance
     In vitro Bio-Pharmaceutical Interactions
     Pharmacokinetic Interactions
     Pharmacodynamic Interactions
     Question Bank

Chapter 8. Controlled Drug Delivery Systems
     General Principles
     Selection of Drug for Controlled Drug Delivery Systems
     Design of Controlled Drug Delivery System
     Kinetics of Drug Release—Controlled Drug Delivery Systems
     Question Bank

Chapter 9. Introduction to Pharmacokinetics
     Pharmacokinetic Models
     Compartment Models
     Physiological Models
     Question Bank

Chapter 10. Pharmacokinetic Models—Drug Disposition
     One Compartment Open Model—Drug Disposition
     Plasma Elimination Half Life—One-Compartment Open Model
     Multi exponential Decay—Drug Disposition
     Two-Compartment Open Model—Drug Disposition
     Three-Compartment Open Model—Drug Disposition
     Question Bank
Chapter 11. Drug Distribution in the Body
     Apparent Volume of Distribution—One-Compartment Open Model
     Apparent Volume of Distribution—Two-Compartment Open Mode
     Real Volume of Distribution
     Factors Influencing Drug Distribution
     Question Bank

Chapter 12. Protein Binding of Drugs
     Implications of Drug—Protein Binding
     Blood Proteins—Characteristics
     Factors Affecting Drug—Protein Binding
     Kinetics of Drug-Protein Binding
     Drug-Protein Binding—Experimental Methods
     Protein Binding—Diseased State
     Question Bank

Chapter 13. Biotransformation of Drugs
     Metabolizing Organs, Enzymes and Reactions
     Pathways of Drug Biotransformation
     Phase I Biotransformation Reactions
     Phase II Biotransformation Reactions
     Factors Affecting Biotransformation of Drugs
     Pharmacokinetics of Drug Metabolism
     First-Pass Effect
     Question Bank

Chapter 14. Excretion of Drugs
     Renal Excretion of Drugs
     Mechanisms of Renal Excretion of Drugs
     Factors Influencing Renal Excretion of Drugs
     Non-renal Routes of Drug Excretion
     Question Bank

Chapter 15. Drug Elimination - Clearance Concepts
     Renal Clearance
     Hepatic Clearance
     Organ Clearance
     Biliary Clearance
     Question Bank

Chapter 16. Pharmacokinetics of Drug Absorption
     Zero Order absorption kinetics
     First Order absorption kinetics—One Compartment Open Model
     Wagner-Nelson Method—Determination of ka
     Urine Data—Determination of Parameters
     Two Compartment Open Model—Loo-Reigelman Method
     Variations in Plasma Drug-Time Curves—Oral Administration
     Question Bank

Chapter 17. Constant Rate Infusion—Pharmacokinetics
     Infusion—One Compartment Open Model
     Infusion—Two Compartment Open Model
     Infusion Plus Loading Dose—One Compartment Open Model
     Infusion Plus Loading Dose—Two Compartment Open Model
     Question Bank
Chapter 18. Multiple Dosage Regimen
     Drug Accumulation—Multiple Dosing
     Intravenous Injection—Multiple Dosing
     Oral Dosage Regimen—Multiple Dosing
     Loading Dose and Multiple i.v. Dosing
     Loading Dose and Multiple Oral Dosing
     Scheduling of Dosage Regimen
     Question Bank
Chapter 19. Nonlinear Pharmacokinetics
     Saturable Enzymatic Elimination—Michaelis-Menten Kinetics
     Drug Elimination—Capacity Limited Pharmacokinetics
     Determination of Km and Vm—Methods
     Question bank
Chapter 20. Doses—Fixing, Adjustment and Individualization
     Determination of Dose
     Dose Adjustment in Certain Groups
     Design of Dosage Regimen
     Hepatic Disease—Dose Adjustment
     Renal Disease—Dose Adjustment
     Individualisation of Therapy
     Therapeutic Drug Monitoring
     Population Pharmacokinetics
     Question Bank
Chapter 21. Non-Compartment Models—Pharmacokinetics
     Statistical Moment Theory and Categorisation of Moments
     Noncompartment Models—Pharmacokinetic Parameters
     Question Bank
Appendix-I   : Definitions and Meanings
Appendix-II  : All in Twos—Know Them Well
Appendix-III : Bibliography
Appendix-IV : Answers to Numerical Problems