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About The Book
This book presents a complete picture of all the aspects of drug designing and development. The book has been divided into five sections. Section A gives the introduction of the subject in first two chapters. Section B deals with four chapters on structural designing of molecules by means of chemical modifications. Section C covers three chapters dedicated to designing of enzyme inhibitors and peptidomimetics. Section D is the most sought-after section, devoted to theoretical designing of drugs, including all the techniques involving molecular modeling. Contents of this section are covered in eight chapters covering all the theoretical aspects of drug designing. Section E lists two special chapters, one on enzyme kinetics and the other on the basics of computational chemistry.
Being a comprehensive book on the subject of drug designing, all the aspects of drug designing given in the revised syllabi of B.Pharm and M.Pharm by PCI, are covered in this book. Any future revision of syllabi covering the subject of drug design is also taken care by full coverage of the subject in this book.
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Content
A. INTRODUCTION
1. Lead Identification
2. Lead Optimization
B. STRUCTURAL DESIGNING
3. Designing of Analogs
4. Prodrug Designing
5. Designing of Identical Hybrid Drugs and Multi-Potent Drugs
6. Drug Solubilizing Strategies
C. DESIGNING OF ENZYME INHIBITORS
7. Enzyme Inhibition in Drug Discovery
8. Enzyme Inhibitors as Drugs
9. Designing of Peptidomimetics
D. THEORETICAL DRUG DESIGNING
10. Theoretical Drug Designing- Some Considerations
11. QSAR Appoaches-1: Hansch’s Extrathermodynamic Approach
12. Parameterization of Structures-Electronic Descriptors
13. Parameterization of Structures-Steric Descriptors
14. Parameterization of Structures-Hydrophobicity
15. Strategies in Test Series Designing
16. QSAR Approaches-2: Free and Wilson Model
17. Molecular Modeling
E. SPECIAL CHAPTERS
18. Enzyme Kinetics
19. Basics of Computational Chemistry
GLOSSARY OF TERMS
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