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  Though the Pharmaceutical Chemistry curriculum has remained unchanged and the Education Regulations 1991 prescribed by the Pharmacy Council of India, remains the guiding roadmap in shaping this book, yet from time to time revisions of Indian Pharmacopeia (IP) has encouraged us to revise the book in 2004, which was reprinted nine times and now the third edition is out in 2013.

  The present edition has been aligned with the Indian Pharmacopeia 2010.

1. Introduction

2. Common Inorganic Pharmaceutical Compounds

       General discussion including important physical and chemical properties, medicinal and pharmaceutical uses, storage conditions and chemical incompatibility on the following inorganic compounds.

       (A)   Acids, bases and buffers

                    Boric acid

                    Hydrochloric acid

                    Strong ammonium hydroxide

                    Calcium hydroxide

                    Sodium hydroxide

                    Official buffers

       (B)   Antioxidants

                    Hypophosphorous acid Sulphur dioxide Sodium bisulphite Sodium metabisulphite Sodium thiosulphate Sodium nitrite

                    Nitrogen

        (C) Gastrointestinal agents

             (i)   Acidifying agents

        Dilute hydrochloric acid

            (ii)   Antacids

                    Sodium bicarbonate

                    Aluminium hydroxide gel

                    Aluminium phosphate

                    Calcium carbonate

                    Magnesium oxide

                    Magnesium carbonate

                    Magnesium trisilicate

                    Combinations of antacid preparations

          (iii)   Protectives and adsorbents

                    Bismuth subcarbonate

                    Kaolin       

                    Saline cathartics

                    Sodium potassium tartrate

                    Magnesium sulphate

        (D) Topical agents

             (i)   Protectives

                    Talc

                    Zinc oxide

                    Calamine

                    Zinc stearate

                    Titanium dioxide

                    Silicone polymers

            (ii)   Antimicrobials and astringents

                    Hydrogen peroxide

                    Potassium permanganate

                    Chlorinated lime

                    Iodine

                    Solutions of iodine

                    Povidone-iodine

                    Boric acid

                    Borax

                    Silver nitrate

                    Mild silver protein

                    Mercury

                    Yellow mercuric oxide

                    Ammoniated mercury

                    Zinc undecylenate

                    Sodium antimony gluconate 

          (iii)   Sulphur and its compounds

                    Precipitated sulphur

                    Sublimed sulphur

                    Selenium sulphide

           (iv)   Astringent

          Alum Zinc sulphate

        (E)  Dental products

                    Sodium fluoride

                    Stannous fluoride

                    Calcium carbonate

                    Sodium meta phosphate

                    Dicalcium phosphate

                    Strontium chloride

                    Zinc chloride

        (F) Inhalants

                    Nitrogen

                    Oxygen Carbon dioxide Nitrous oxide

        (G) Respiratory stimulants

                    Ammonium carbonate

        (H) Expectorants and Emetics

                    Ammonium chloride Potassium iodide Antimony potassium tartrate

        (I)    Antidotes

                    Sodium nitrite

  3. Major Intra- and Extra-cellular Electrolytes

       (A)   Electrolytes used for replacement therapy

                    Sodium chloride and its preparations

                    Potassium chloride and its preparations

       (B)   Physiological acid-base balance and electrolytes used

                    Sodium acetate

                    Potassium acetate

                    Sodium bicarbonate injection

                    Sodium citrate

                    Potassium citrate

                    Sodium lactate injection

                    Ammonium chloride and its injection

       (C)   Combination of oral electrolyte powders and solutions

                    Oral Rehydration Therapy

4. Inorganic Official Compounds of Iron, Iodine, and Calcium

                Ferrous sulphate Iodine Calcium gluconate

5. Radio-pharmaceuticals and Contrast Media

       Radiopharmaceuticals

                Structure of an atom

                Radioactivity—Alpha, Beta and Gamma Radiations

                Biological effects of radiations

                Measurement of radio-activity

                G. M. Counters 

                Applications of radioisotopes

       Radiopaque/Contrast Media

                Barium sulphate

6. Quality Control of Drugs and Pharmaceuticals                   

                Importance of quality control

                Significant figures

                Methods used for quality control

                Sources of impurities in pharmaceuticals

                Assays

              Gravimetric

              Volumetric

              Acidimetry-Alkalimetry

              Oxidation-Reduction (Redox Type)

              Iodometric and Iodimetric Types

              Precipitation Types

              Comlexometric Type

                Limit tests for chloride

                Limit tests for sulphate

                Limit tests for iron

                Limit tests for lead

                Limit tests for heavy metals

                Limit tests for arsenic

7. Identification Tests for Cations and Anions 

APPENDIX

         Glossary of Medical and Chemical Terms