The Laboratory Manual of Physical Pharmacy–I contains several important experiments expected to be conducted during the first year B.Pharm course. During the first year of B. Pharm., the students are exposed for the first time to the professional aspects such as pharmacopœial specifications of drugs, standardization and calibration of instruments, apart from the evaluation of physical properties in a laboratory.
    This laboratory manual consists of twenty experiments to be conducted during the year. Broadly, the physical and chemical properties included are: density, viscosity, refractive index, optical activity, partition coefficient, critical solution temperature, surface tension, pH, dissociation constant, colligative properties, solubility cosolvency, heat of neutralization, transition temperature etc.
    Special emphasis has been given on the following:
       1. Concepts and principles are applied to pharmacy.
       2. Model calculations for each experiment help the user in processing and analysing the raw data independently.
       3. Illustrations facilitate the students in handling the instruments and organizing ones laboratory work in a cohesive manner.
       4. Question Bank for guiding students to improve performance.
In fact this book will be found useful for ‘self learning’. It will also serve as a ready reference for the industrial pharmacist.
A special attention is given to change the units from CGS system to SI system. Therefore an appendix has been included for the purpose of interconversion.

    Glossary of Symbols

EXPERIMENTS
    1. Physical Properties of Liquids
    2. Viscosity of Liquids
    3. Refractive Index of Liquids
    4. Distribution Coefficient—Iodine
    5. Phenol-Water System—CST
    6. Percent Composition—Polarimeter
    7. Percent Composition—Capillary Flow Method
    8. Sodium Chloride—CST
    9. Distribution Coefficient—Benzoic Acid
   10. Surface Tension—Parachor
   11. pH Estimation—pH Meter
   12. pH Estimation—Colourimetric Method
   13. Dissociation Constant—Conductivity Method
   14. Molecular Weight—Landsberger's Method
   15. Molecular Weight—Rast-Camphor Method
   16. Solubility Determination—Heat of Solution
   17. Dissociation Constant—Distribution Method
   18. Heat of Neutralisation of Acid
   19. Solubility Cosolvency
   20. Transition Temperature of Hydrates

APPENDICES
   I Units and constants
   II Notations/Abbreviations and Interconversion of uints
   III Definitions and Meanings
   IV All in Twos—Know Them Well