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About The Book
The Laboratory Manual of Physical Pharmaceutics contains several important experiments to be conducted during B. Pharm. course.
The prime intention of the authors is to facilitate the students in comprehension and understanding of the subject properly through practical work. In fact, this book will be found useful for ‘self-learning’. The entire information is made available at one place. It will also serve as a ready reference to the industrial pharmacist.
This Laboratory Manual consists of 20 experiments to be conducted during the year. There is a proper blend of various aspects concerned with preformulation and dispersion dosage forms. Preformulation aspects involve the evaluation of the order of chemical reactions, predicting the drug stability, interfacial properties, powder and particle characteristics, complexation etc. Preparation and evaluation of colloids, suspensions and emulsions have been included.
Special emphasis is laid on the following
1. Concepts, principles and applications are illustrated.
2. Model calculations for each experiment will help the user in processing and analysing the raw data independently.
3. Question bank is added for guidance of the students to improve performance.
Content
Greek Alphabets
Glossary of Symbols
1. Acid Hydrolysis of Ester—First Order Rate Constant
2. HLB Determination of Surfactant—Saponification Method
3. Cmc of a Surfactant—Surface Tension (Drop Count) Method
4. Flow Properties—Powders or Granules
5. Suspensions—Physical Stability, Sedimentation Volume
6. Alkali Hydrolysis of Ester—Second Order Rate Constant
7. Bulk Density, True Density and Porosity—Powders
8. Particle Size Distribution—Microscopy
9. Cmc of a Surfactant—Conductivity Method
10. Analysis of Complexation—Solubility Method
11. Cmc of a Surfactant—Capillary Rise Method
12. Emulsions—Identification and Physical Stability
13. Adsorption Studies—Acetic Acid on Charcoal
14. Particle Size Distribution—Sieving Method
15. Complexation—pH Titration Method
16. Accelerated Stability Studies—Aspirin Solution
17. Interfacial Tension—DuNouy Tensiometer
18. Sulphur Colloids—Preparation and Physical Stability
19. Flocculated Suspensions—Preparation and Evaluation
20. Dissolution Studies—Oxytetracycline Hard Gelatin Capsules
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