Advanced Physical Pharmaceutics
  by CVS Subrahmanyam / J Thimmasetty / PR Sathesh Babu
 
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   ISBN 978-93-85529-29-0; First Ed. 2020; pp.viii+544

   Delhi price: 420      Outside Delhi price: 440      Overseas price : 1260

 About The Book  

This book focuses on the needs of postgraduate studies. Physicochemical properties of materials (drugs & excipients) form an essential part of Physical Pharmaceutics and advanced topics are explained. Nanotechnology demands the determination of particle size as a crucial point in the preformulation of dosage forms. Polymers have been widely used in the conventional formulations and novel controlled drug delivery systems. The evaluation of the release mechanisms is the key to the product development. The characterization of materials by the thermal analysis and X-ray diffraction becomes important as pharmacopoeial necessities. These are based on the improvements as needed by the pharmaceutical industry and research.

   Special emphasis is given to include the following:
          1. Conceptualization of principles
          2. Applications of principles
          3. A number of illustrations
          4. Comments type questions
          5. Objectives and mind maps
          6. Question bank

 Content


Chapter 1. PARTICLE SIZE ANALYSIS TECHNOLOGIES
     Laser Diffraction - Particle Size Analyzer
     Dynamic Light Scattering – Particle Size Analyzer
     Sedimentation Method – SediGraph
     Non Invasive Back Scattering (NIBS) Technology
     Electron Microscopic Methods
     Automated Imaging – Particle Size
     Nanoparticle Size – Biodistribution
     Question Bank

Chapter 2. VISCOELASTICITY
     Oscillatory Testing
     Creep Measurement
     Miscellaneous Methods of Rheometry
     Mechanical Modeling of Viscoelastic Materials
     Psychorheology
     Question Bank

Chapter 3. COMPACTION – COMPRESSION AND CONSOLIDATION
     General Principles
     Compression
     Consolidation
     Decompression
     Compaction at High Loads
     Forces Distribution during Compression
     Compaction Profiles
     Forces in Compression – Measurement
     Energy involved in Compaction
     Properties of Granules for Compression
     Properties Related to Machinery for Compression
     Influence of Compression Force on the Properties of Tablets
     Question Bank

Chapter 4. POLYMERS – PHYSICOCHEMICAL PRINCIPLES
     Classification of Polymers
     Polymerization Mechanisms
     Polymerization Methods
     Fabrication of Polymers
     Solvent Mediated Fabrication of Polymers
     Melt Polymer Fabrication Techniques
     Characterization of Polymers
     Question Bank

Chapter 5. POLYMERS – DRUG DELIVERY SYSTEMS
     Mucoadhesive Polymers – Drug Delivery Systems
     Polymers – Hydrodynamically Balanced Systems (HBS)
     Polymers – Activation Modulated Systems
     Polymers – Feedback Regulated Systems
     Bioerodible Polymers
     Bioerodible Polymers – Drug Polymer Matrix
     Bioerodible Polymers – Rate Controlling Membrane
     Polymers – Covalent Linkage with Drugs
     Non-Biodegradable Polymers
     Polymers – Colon Drug Delivery Systems
     Polymers – Transdermal Drug Delivery Systems (TDDS)
     Polymeric Carriers for Poorly Water-Soluble Drugs
     Polymer Selection – Factors Affecting
     Question Bank

 
Chapter 6. DRUG RELEASE MECHANISMS – MODELS AND MODELING
     Dissolution mediated Release
     Dissolution Methods (Models)
     Dissolution Release Modeling
     Diffusion Mediated Release
     Diffusion Methods (Models)
     Drug Diffusion Release Modeling – Matrix Systems
     Drug Diffusion Release modeling – Reservoir Systems
     Drug Release Modeling – Swelling Matrix Systems
     Drug Release - Bioerodible Polymer Drug Delivery Systems
     Drug Release - Osmotic Pressure – Activated Systems
     Drug Release Profiles Comparison
     Drug Release Studies – Practical Considerations
     Question Bank

Chapter 7. DIFFERENTIAL SCANNING CALORIMETRY
     Factors Influencing Thermal Analysis by DSC
     Instrumentation of DSC
     Applications of DSC
     DSC – Other Complimentary Methods
     DSC – Modifications
     Question Bank

Chapter 8. THERMOGRAVIMETRY
     Factors Influencing TGA
     Instrumentation of TGA
     Applications of TGA
     Question Bank

Chapter 9. THERMOMECHANICAL ANALYSIS
     Instrumentation
     Applications of TMA
     Question Bank

Chapter 10. X-RAY DIFFRACTION METHOD – THEORY AND APPLICATIONS
     Instrumentation of X-Ray Diffraction Method
     Applications of X-ray Diffraction Method
     XRD - Quantitative Analysis
     XRD – Temperature Related Analysis
     X-Ray Diffraction– Other Complimentary Methods
     Question Bank

APPENDIX-I   : Answers to Comments
APPENDIX-II  : Definitions and Meanings
APPENDIX-III : All in Twos – Know Them Well
APPENDIX-IV : Glossary of Symbols
APPENDIX-V   : Abbreviations
APPENDIX-VI  : Bibliography