This book is concerned with several aspects related to the fate of drug in body, quantification of a drug in processes such as absorption, distribution, biotransformation and excretion. These aspects are applied in treatment situations and design of dosage forms. The content will help students to master the concepts, train them regarding hands-on-work & computer aided calculations of PK parameters. This book will be useful for the B.Pharmacy, 6^th semester & M.Pharmacy, 2^nd semester as well as by PG level students.
   There are 40 assignments and each assignment is provided with practice problems. Special emphasis is given to include the following:-
       –  Conceptualisation of Principles
       –  Applications of Principles
       –  A number of Illustrations
       –  Question Bank

EVALUATION OF PHARMACOKINETIC PARAMETERS
  1. Plasma Drug Level-Time Curves – One Compartment Open Model Disposition
  2. Urine Drug Level-Time Curves – One Compartment Open Model Disposition
  3. Plasma Drug Level-Time Curves – Two Compartment Model Disposition
  4. Plasma Drug Level-Time Curves – AUC-Trapezoid Method
  5. Plasma Drug Level-Time Curves – Oral Absorption Kinetics
  6. Absorption Rate Constant – One Compartment Model – Wagner-Nelson Method
  7. Absorption Rate Constant – Two Compartment Model – Loo-Reigleman Method

BIOAVAILABILITY AND BIOEQUIVALENCE
  8. Serum Levels of Oral Products
  9. Linear Pharmacokinetics – Bioavailability – One Compartment Open Model
10. Linear Pharmacokinetics – Bioavailability – Two Compartment Open Model
11. Testing of Significant Differences among the Treatments
12. Mean Resident Time – Non-Compartment Analysis

DRUG DISSOLUTION STUDIES – ANALYSIS
13. Drug Dissolution Profiles Comparison – Dissolution Efficiency (%)
14. Drug Dissolution Profiles Comparison – Mean Dissolution Time
15. Drug Dissolution Profiles Comparison – f₁ and f₂

DRUG RELEASE STUDIES – ANALYSIS
16. Drug Release Aanalysis – Controlled Delivery System

DDSOLVER – ADD-INS PROGRAM FOR DISSOLUTION MODELING
17. Computer Aided Dissolution Analysis – Release Modeling
18. Computer Aided Dissolution Analysis – Controlled Release Modeling
19. Computer Aided Dissolution Analysis – Comparison of Two Products Profiles
20. Computer Aided Drug Dissolution Profiles – Comparison of Profiles

PKSOLVER – ADD-INS PROGRAM FOR PK AND PD MODELING
21. Computer Aided PK Analysis – One Compartment Open Model Disposition
22. Computer Aided PK Analysis – Two Compartment Open Model Disposition
23. Computer Aided PK Analysis – Oral Absorption Kinetics
24. Computer Aided PK Analysis – Continuous Infusion Profile Modeling
25. Computer Aided PK Analysis – Non-Compartment Analysis

ANALYTICAL METHODS OF DRUGS
26. Analytical Method – Aspirin
27. Analytical Method – Oxytetracycline
28. Analytical Method – Dopamine
29. Analytical Method – Labetalol
30. Analytical Method – Ibuprofen
31. Analytical Method – Diclofenac
32. Analytical Method – Paracetamol

EXPERIMENTS – BIOPHARMACEUTICS AND PHARMACOKINETICS
33. Influence of Particle Size on the Release of Aspirin – Dissolution Studies
34. Protein Binding Studies of Oxytetracycline
35. Binding of Dopamine with Insulin
36. Pharmacokinetics of Paracetamol by Saliva Analysis
37. Bioavailability of Ampicllin by Urine Analysis
38. Buccal Mucosal Absorption Test for Chlorpheniramine Maleate
39. Rat Everted Intestinal Sac Method – In Situ Drug Absorption
40. In Situ Rat Gut Method–Drug Absorption

APPENDICES
  1. Glossary of Symbol
  2. Student Consent Form
  3. Bibliography