Chapter 1. SOLUBILITY PHENOMENON
Mechanisms of Interactions—Intermolecular Forces
Factors Influencing the Intermolecular Forces
Classification of Solvents for the Solubility
Methods of Expressing Solubility
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Chapter 2. SOLUBILITY OF SOLIDS IN LIQUIDS
Determination of Solubility of Solids in Liquids
Factors Influencing Solubility of Drugs
Theories of Solutions
Solubility Parameters
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Chapter 3. DRUG DISSOLUTION
Dissolution-Drug Absorption
Dissolution-Tablets and Capsules
Theories of Dissolution
Mathematical Treatment - Dissolution
Factors Influencing Dissolution
Dissolution Test Apparatus
Vitro-In Vivo Correlations of Dissolution
Powder Dissolution—The Hixson Crowell Cube Root Law
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Chapter 4. DIFFUSION
Steady State Diffusion
Methods and Procedures
Transport of Drugs Across Gastrointestinal Tract
Diffusion Controlled Release—Higuchi Equation
Biopharmaceutics Classification System
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Chapter 5. SOLUBILITY OF GASES IN LIQUIDS
Factors Influencing Solubility of Gases in Liquids
Ostwald’s Solubility Coefficient
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Chapter 6. SOLUBILITY OF LIQUIDS IN LIQUIDS
Miscible Liquids
Ideal Solutions
Non-ideal Solutions or Real Solutions
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Chapter 7. PARTIALLY MISCIBLE LIQUIDS
Phenol—Water System
Triethylamine—Water System
Nicotine—Water System
Influence of Foreign Substances
Method of Determination
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Chapter 8. DISTRIBUTION LAW
Measurement of Partition Coefficient
Influence of Molecular Association on Partition Coefficient
Influence of Dissociation on Partition Coefficient
Applications
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Chapter 9. GASEOUS STATE
Ideal Gas Equation
Real Gases-van der Waals Equation
Dalton’s Law of Partial Pressures
Graham’s Law of Diffusion
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Chapter 10. LIQUID STATE
Characteristic Properties of Liquids
Liquefaction of Gases
Supercritical Fluids
Liquid Crystals (Meso) Phase
Liquid Complexes
Micellar Solubilization
Aerosols—Inhalers
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