Biopharmaceutics and Pharmacokinetics—Concepts & Applications
  by C.V.S. Subrahmanyam
 
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   ISBN 978-93-85529-33-7; Third Ed. 2021; pp.x+326;

   Delhi price: 420      Outside Delhi price: 440      Overseas price : 1260

 About The Book  

The content area is reorganized as per the PCI and is exclusively meant for B. Pharmacy and Pharm.D course requirements. The focus includes applications of physicochemical properties of drug molecules, dosage forms and clinical implications. Drug absorption and evaluation of dosage forms are given adequate stress along with associated properties.

The book involves the quantification of drug in different processes, such as absorption, distribution, biotransformation and excretion. Several these aspects are important in the clinical situations. This is a basic level book which is normally important for third/final year of B. Pharm. course. These topics are so important that at PG level also these are included. The students of IV year, Bachelor of Pharmacy have been expressing the need for a simple book. This book will help learning calculating the pharmacokinetics parameters.

The book is broadly divided into Biopharmaceutics part and Pharmacokinetics part. Special emphasis is given to include the following:
     1. Conceptualisation of principles.
     2. Applications of principles.
     3. A number of illustrations.
     4. Question bank.

 Content


Chapter 1. Introduction to Biopharmaceutics
     Fate of Drug in the Body
     Blood Drug Level –Time Analysis
     Urine Drug Level – Time Analysis
     Drug Concentration in Saliva
     Drug Concentration in Feces
     Experimental Studies – Models
     Question Bank

Chapter 2. Drug Absorption—Factors Influencing
     Gastrointestinal Tract—Physiology
     Mechanisms of Drug Absorption in Gastrointestinal Tract
     Biological Factors Influencing Drug Absorption
     Metabolic Factors Influencing Drug Absorption
     Physicochemical Factors Influencing Drug Absorption
     Dietary Components Influencing Drug Absorption
     Formulation Related Factors Affecting Drug Absorption
     Role of Dosage Forms on Drug Absorption
     Role of Manufacturing/Processing Variables on Drug Absorption
     Absorption of Drugs from Non-oral Extravascular Routes
     Question Bank

Chapter 3. Drug Dissolution
     Real Volume of Distribution
     Factors Influencing Dissolution
     Specialized Physiological Barriers for Drug Distribution
     Question Bank

Chapter 4. Protein Binding of Drugs
     Implications of Drug – Protein Binding
     Blood Proteins – Characteristics
     Factors Affecting Drug – Protein Binding
     Kinetics of Drug – Protein Binding
     Drug-Protein Binding – Experimental Methods
     Protein Binding – Diseased State
     Question Bank

Chapter 5. Biotransformation of Drugs
     Metabolizing Organs, Enzymes and Reactions
     Pathways of Drug Biotransformations
     Phase I Biotransformation Reactions
     Phase II Biotransformation Reactions
     Factors Affecting Biotransformation of Drugs
     Question Bank

Chapter 6. Excretion of Drugs
     Renal Excretion of Drugs
     Mechanisms of Renal Excretion of Drugs
     Factors Influencing Renal Excretion of Drugs
     Nonrenal Routes of Drug Excretion
     Question Bank

Chapter 7. Dosage Form Evaluation – Bioavailability
     General Principles
     Extent of Bioavailability
     Rate of Bioavailability
     Assessing Bioavailability – Methods
     Multiple Dosing – Bioavailability
     In Vitro Bioavailability Studies (Dissolution)
     In Vitro – In Vivo Correlations (IVIVC)
     Biopharmaceutics Classification System
     Enhancing the Bioavailability – Strategies
     Question Bank

Chapter 8. Dosage Form Evaluation - Bioequivalence
     General Principles
     Bioequivalence Requirement – Criteria
     Bioequivalence Requirement – Criteria for Biowaiver
     Bioequivalence Studies – Methodology 165PHARMACOKINETICS
     Question Bank

 
Chapter 9. Introduction to Pharmacokinetics
     Pharmacokinetic Models
     Compartment Models
     Physiological Models
     Non-compartment Models
     Question Bank

Chapter 10. Drug Disposition Kinetics – One Compartment Model
     One Compartment Open Model – IV Bolus Injection
     Plasma Elimination Half Life
     Apparent Volume of Distribution – IV Bolus Injection
     Kinetics of Drug Metabolism – PK Parameters
     Drug Metabolism – First-Pass Effect
     Drug Renal Excretion Kinetics – PK Parameters
     Question Bank

Chapter 11. One Compartment Drug Disposition – Infusion
     Constant Rate Infusion
     Infusion Plus Loading Dose
     Chapter 12. One Compartment Model – Absorption Kinetics
     Zero Order Absorption Kinetics
     First Order Absorption Kinetics
     Wagner-Nelson Method – Determination of ka
     Urine Data – Determination of Parameters
     Variations in Plasma Drug - Time Curves – Oral Administration
     Question Bank

Chapter 13. Multicompartment Models – Pharmacokinetics
     Two Compartment Open Model – IV Bolus Injection
     Apparent Volume of Distribution – Two Compartment Open Model
     Infusion – Two Compartment Open Model
     Infusion Plus Loading Dose
     Drug Absorption Kinetics – Two Compartment Open Model –
        Loo-Reigelman Method
     Question Bank

Chapter 14. Drug Elimination – Clearance Concepts
     Clearance
     Renal Clearance
     Hepatic Clearance
     Organ Clearance
     Biliary Clearance
     Question Bank

Chapter 15. Multiple Dosage Regimen – Pharmacokinetics
     Drug Accumulation – Multiple Dosing
     Intravenous Injection – Multiple Dosing
     Oral Dosage Regimen – Multiple Dosing
     Loading Dose and Multiple IV Dosing
     Loading Dose and Multiple Oral Dosing
     Scheduling of Dosage Regimen
     Question Bank

Chapter 16. Nonlinear Pharmacokinetics
     Saturable Enzymatic Elimination – Michaelis-Menten Kinetics
     Drug Elimination – Capacity Limited Pharmacokinetics
     Determination of Km and Vm – Methods
     Question Bank

Appendix-I   : Definitions and Meanings
Appendix-II  : All in Twos—Know Them Well
Appendix-III : Bibliography
Appendix-IV : Answers to Numerical Problems
Appendix-V  : Key to MCQs